Pharma 800x200

The world’s top 20 pharmaceuticals companies use DVS method

Pharmaceuticals materials, in their many physical forms, offer a wide range of complex behavior, often dependent on their complex crystalline and amorphous morphologies. Surface Measurement Systems instruments have become the industry standard for the characterisation of solid state dosage forms in the pharmaceutical industry.

The moisture sorption properties of many solid state materials, especially organic materials are critical for the characterisation of their drying and shelf life stability. In the past 10 years the DVS method invented by Surface Measurement Systems has become the standard laboratory method for studying drying and dehydration behaviour.

Application Note 36: Investigation of Hydrate Formation and Loss Using the DVS | Request a copy

The amorphous content of pharmaceutical solids is a critical materials property. The DVS method has become the industry standard method now for determining amorphous content in pharmaceutical solids, and can routine determine amorphous contents of less than 0.1% using gravimetric DVS experiments.

 

Application Note 44: Determining Amorphous Contents without a Standard Hydrate/Solvate Stoichiometry | Request a copy

Increasing numbers of pharmaceutical candidate materials are found to exist as crystalline hydrates. In general such organic hydrates exhibit variable stability, which can be strongly dependent on temperature and relative humidity. DVS instruments, combined with video imaging and Raman are ideal for mapping our the stability behaviour of pharmaceutical hydrates.

Application Note 36: Investigation of Hydrate Formation and Loss Using the DVS | Request a copy

Application Note 41: Investigation of Solvate Formation and Loss Using the DVS | Request a copy

Application Note 42:Using the DVS to Investigate Moisture-Induced Crystallization Kinetics | Request a copy

Application Note 45: Investigation of Desolvation Kinetics Using the DVS | Request a copy

The vapour pressure is an important property of solid state materials where is is a key property for environmental and stability reasons.The DVS Vacuum can determine the vapour pressure of solids using the well established Knudsen cell method. The vapour pressure of solids is a property that reflects both thermodynamic stability and shelf life of solids.

Application Note 48: Vapour Pressure Measurement of Pesticides using the DVS Knudsen Method | Request a copy

The moisture sorption properties of many solid state pharmaceutical materials, both crystalline and amorphous, are critical to understanding their chemical and physical stability in the presence of moisture. In the past 20 years the DVS method invented by Surface Measurement Systems has become the standard laboratory method for measuring water sorption isotherms of pharmaceutical materials.

 

Application Note 02: Moisture Sorption of EC Standard Reference Material RM 302 on a DVS-1 Instrument | Request a copy

 

Application Note 03: Polymorphism in Spray Dried Lactose | Request a copy

 

Application Note 13: Moisture Sorption of Hydrophobic Pharmaceutical Substances | Request a copy

It is well established that polymorphs of crystalline pharmaceutical solids often exhibit differing water sorption behavior. So not only can water sorption data be useful for establishing with polymorph has the best water sorption stability, it can also be used as a routine way for differentiating between different polymorphic forms that might be present.

 

Application Note 41: Investigation of Solvate Formation and Loss Using the DVS | Request a copy

Studying molecular diffusion and permeability in pharmaceutical is central to understanding and optimising their performance. The DVS and SEA instruments allows such phenomena to be studied using a wide range of probe molecules including water, organic solvents and gases, depending upon the specific SMS instrument used. SMS instruments are ideal for obtaining both kinetic and equilibrium information on molecular diffusion and permeability in a wide range of pharmaceutical materials.

 

Application Note 12: Absolute Measurement of Moisture Diffusion into Blister Packaging Systems | Request a copy

Application Note 30: Calculation of Diffusion Constants in a Pharmaceutical Powder using DVS | Request a copy

Application Note 52: Vapor Permeability of Porous Materials using Payne Diffusion Cell | Request a copy

The chemical, morphological and physical stability of pharmaceutical products to water vapour is key to both product performance and long term product storage. The DVS range of instruments are ideal for studying the moisture stability of a range of dosage forms such as granules, capsules, powders and tablets across a wide range of real world temperatures.

Application Note 03: Polymorphism in Spray Dried Lactose | Request a copy

Application Note 33: Impact of Protein Concentration on the Moisture-Induced Phase Transitions of Protein-Sugar Formulations | Request a copy

Screening the performance of a range of different pharmaceutical formulations in the presence of water vapour can be easily achieved using the DVS approach. DVS measurements are ideal for studying the formulation performance of a range of dosage forms such as granules, capsules, powders and tablets, as well as the raw ingredients which make up the final product such as API’s, excipients and binders.

 

Application Note 03: Polymorphism in Spray Dried Lactose | Request a copy

 

Application Note 33: Impact of Protein Concentration on the Moisture-Induced Phase Transitions of Protein-Sugar Formulations | Request a copy