DVS Endeavour
5X Parallel Gravimetric Sorption Analyzer
A key feature of DVS Endeavour is the ability to precisely control and measure temperature and relative humidity while simultaneously recording the highest resolution changes in mass on up to 5 samples. Additionally Organic vapor partial pressures can now be directly measured using Surface Measurement Systems’ Speed of Sound sensor (patented). In a typical experiment a known concentration of water vapor or organic vapor is delivered over a sample placed inside the sample pan. The sample pan is connected to the Surface Measurement Systems Ultrabalance measuring real-time mass changes caused by sorption or desorption of water and/or organic molecules.
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Outstanding capabilities
Simultaneous
5x sample
measurement
Organic and
Water vapor
sorption kinetics
Organic vapor sorption in a fixed RH background
Real time partial pressure control & measurement
Water & organic vapor sorption isotherms from 10-70 °C
In-situ drying
of samples
to 200 °C
Optional
Color Video
Microscopy
TrueO
drying at
0.0% RH
- Real-time simultaneous parallel mass measurements and sorption kinetics for up to 5 samples
- Individual sample chamber isolation preventing crossover contamination
- Sample masses from 1 mg to 5000 mg
- Water and organic vapor sorption kinetics and control using patented Speed of Sound vapor sensor measurementtechnology
- Multiple sorption/desorption, temperature and sample drying or activation cycles
Lot-to-Lot Moisture Sorption/Desorption Variation of Microcrystalline Cellulose
- Investigation of batch-to-batch variation in raw materials and production technicalsupport
- Ingredient compatibility
- Quality control for excipients, actives and formulations
- Stability studies in the selection of new compounds/candidates
- Large scale formulation studies
Moisture Sorption/Desorption variation within the same lot of Crystalline material
- Isotherms and ramped humidity/organic vapor and experiments
- Vapor sorption, vapor exchange and dual vapor co-adsorption
Processing Variations Affect Amorphous Content and Humidity Sorption/Desorption of Milk Powder
- Amorphous content
- Hydrate/solvate formation
- Polymorph identification
- Moisture/solvent induced Tg
Humidity Sorption/Desorption Kinetics and Isotherms
Sorption Isotherms for Moisture and a Series of Organic Vapors
Film Diffusion Coefficient for Moisture Barrier Coatings
Temperature
Temperature controlled enclosure
- Control range: 10 °C to 70 °C
- Regulation precision: ± 0.1 oC
- Enclosure also provides anti-condensation protection
High temperature pre-heater for drying samples up to 200 °C
- 200 °C (maximum local temperature)
- Heating ramp rates: up to 10 °C/min
- Temperature Sensor: Pt-100
Endeavour Stand
- Manifold: 316 stainless steel
- Seals: Viton
- Tubing: 1/4 inch stainless steel
Solvent Reservoirs
- Material: Pyrex glass
- 0.25 and 0.5L as standard
- 2 Reservoirs included
Relative Humidity Generation and Measurement
Flow control
- High accurate digital mass flow controllers
Relative Humidity Sensor
- Capacitance probe
- Carrier Gas – Dry air or Nitrogen
- Relative humidity range from 0 to 98%
- RH range accuracy from 10 – 60 oC ±0.5%
- RH range accuracy from 60 – 70 oC ±1%
Organic Vapor Generation and Measurement Speed of Sound Sensor
- Partial pressure range from 0 to 90%
- P/P0 range accuracy from 10 – 50 oC ±1%
- Speed of Sound Sensor for organic vapors
- Real time partial pressure measurement and control
Solvents Available include:
- Water
- Pentane
- Heptane
- Hexane
- Octane
- Nonane
- Decane
- Cyclohexane
- Methanol
- Ethanol
- Phenol
- Toluene
- Acetone
- Chloroform
- o-Xylene
- m-Xylene
- p-Xylene
- Benzyl Acetate
- Ethyl Acetate
- d-Limonene
- Tetrahydrofuran
- Dioxane
- Dichloromethane
- Isopropanol
Instrument Platform
System Software
Next generation purpose built analysis and evaluation software for
the most advanced experimental design and data control.
DVS Control Software
Multiple-method protocols
incorporating:
- Sample pre-heating
- Vapor sorption
- Vapor exchange
- Dual vapor co-adsorption
- Temperature changes in a single experiment
- Ramp or step changes in relativehumidity
- Automated video image acquisition
- Organic vapor sorption partialpressure
- Temperature stages may be based on fixed-time or user-defined dm/dt criteria
- Complex isotherm experiments
- Experiments may include half, full or multiple partial pressure or temperature cycles
Software Options
Standard
- DVS Control Software
- DVS Standard Analysis
Advanced
- DVS Advanced Analysis Suite
- DVS Isotherm Analysis Suite
21CFR Part 11 software solution is available for all DVS software upon request
Mass Measurement
Ultrabalance Low Mass
- Low Mass SMS microbalance
- Sample mass: between 1 and
- 1000 mg
- Mass change: ±150 mg
- Resolution (precision): 0.01 μg
- Root mean square balance noise: 0.3 μg
Ultrabalance High Mass
- High Mass SMS microbalance
- Sample mass: between 10 and 5000 mg
- Mass change: ±1000 mg
- Resolution (precision): 1 μg
- Root mean square balance noise: 3 μg
For more information, email [email protected].