Application note 47: Determination of True Density
by Dynamic Vapour Sorption
By Majid Naderi, Manaswini Acharya, Armando Garcia and Dan Burnett
The versatility and impact of Dynamic Vapour Sorption (DVS) for the true density measurements of solid powder materials have been investigated. True density measurements on different amounts of Lactose and Avicel (microcrystalline cellulose) samples were successfully determined using DVS and a gas Pycnometer for comparison.
True density is a fundamental parameter required for characterising many solid materials and slurries including: monitoring of structural rearrangement and porosity of carbon and ceramics after calcination, monitoring the composition of pharmaceutical active and excipient ingredients, determination of the reproducibility when blending building materials and determination of the crystallinity of plastic films and polymers as well as pigmented coatings