Webinar: Study of particle cohesion/adhesion and wettability of powders
Date: Thursday, 4 June 2020
Time: 15:00 BST | 16:00 CEST | 10:00 EDT
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Duration: 25 mins plus Q&A
The effect of powder surface chemistry on high shear wet granulation performance for co-agglomerating untreated and silanized D-mannitol powder is discussed. The wetting performance of polyvinylpyrrolidone (PVP) binder solutions was quantified using experimentally determined thermodynamic spreading coefficients, using the surface energy heterogeneity distributions, obtained via inverse gas chromatography (iGC) measurements, for the mannitol powders. Increases in binder wettability of the formulations correlated with increases in both granule size and granule compressive elastic moduli, which are attributed to an increase in interparticle contacts. In conclusion, powder surface chemistry plays a crucial role in final granule properties, even in highly agitated processes such as high shear granulation. The comprehensive characterization of powder surface properties is necessary to facilitate the manufacture of granules with controllable critical attributes.
This webinar will present the study of the role of solid state surface chemistry on the high shear granulation performance of a model pharmaceutical solids.